[BIC-announce] FW: Killam - Tuesday, December 11, 2007

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 
 
Killam Lecture

 

Speaker:  Alan Fine, PhD, VetMD

Department of Physiology & Biophysics

Dalhousie University, Halifax, NS

 

Title:  How Long Term Synaptic Plasticity is Expressed:

Observation on Individual Visualized Synapses in Hippocampus

 

Date:  Tuesday, December 11, 2007

 

Time: 4:00 pm

-------------------------------------

 

Dear colleagues,

 

Our Killam speaker this week is Alan Fine. He uses sophisticated optical

methods to examine the mechanisms underlying synaptic plasticity during
LTP,

In particular using multiphoton technology in slices he has discovered
novel

mechanisms of calcium regulation that are specific to spines and has
shown

in adult animals much of LTP is explained by regulation of release from

presynaptic terminals. He gives a wonderful talk and I hope you can join
me

on Tuesday at 4:00.

-- 

Reid CA, Dixon DB, Takahashi M, Bliss TV, Fine A.

Optical quantal analysis indicates that long-term potentiation at single

hippocampal mossy fiber synapses is expressed through increased release

probability, recruitment of new release sites, and activation of silent

synapses.

J Neurosci. 2004 Apr 7;24(14):3618-26.

 

Emptage NJ, Reid CA, Fine A, Bliss TV.

Optical quantal analysis reveals a presynaptic component of LTP at

hippocampal Schaffer-associational synapses.

Neuron. 2003 Jun 5;38(5):797-804.

 

Ward B, McGuinness L, Akerman CJ, Fine A, Bliss TV, Emptage NJ.

State-dependent mechanisms of LTP expression revealed by optical quantal

analysis.

Neuron. 2006 Nov 22;52(4):649-61.

 

Rusakov DA, Fine A.

Extracellular Ca2+ depletion contributes to fast activity-dependent

modulation of synaptic transmission in the brain.

Neuron. 2003 Jan 23;37(2):287-97.

 

 

Wayne Sossin

Professor, Dept. Neurology and Neurosurgery

William Dawson Scholar

Montreal Neurological Institute

McGill University

Phone: 1-514-398-1486

Email Wayne.sossin at mcgill.ca

 

 

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