[BIC-announce] Killam Lecture- TODAY - Molecular Dynamics of Guided Axon Growth

[Jennifer Chew, Ms.]

PLEASE DIS CARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 

Jennifer Chew
McConnell Brain Imaging Centre
MNI - WB317
3801 University Street
Montreal, Qc  H3A 2B4
Telephone:  514-398-8554
Fax:  514-398-2975

________________________________________
From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Tuesday, March 21, 2006 8:26 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture- TODAY

*****REMINDER*****
 
KILLAM LECTURE
 
Speaker:  Paul Forscher, Ph.D.
Professor, Yale University
 
Title:  Molecular Dynamics of Guided Axon Growth
 
Date:  Tuesday, March 21, 2006
 
Place:  de Grandpre Communication Centre
 
Time:  4:00 pm
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Dear Colleagues,  
 
Dr. Paul Forscher, professor of molecular, cellular and developmental biology at Yale University will be coming to give the Killam seminar on March 21st, 2006.  Dr. Forscher is interested in the molecular dynamics of guided axon growth.  Specifically, his lab has focused its attention on the growth cone , a  specialized guidance device that provides the motility and signal transduction capabilities needed for axon guidance.  His current lab projects are in three related areas
1. Molecular motor and cytoskeletal protein dynamics underlying growth cone motility. 
2. Cell surface receptors involved in target recognition. 
3. Investigation of signal transduction pathways involved in controlling the cytoskeletal protein effectors involved. 
The Forscher lab addresses  the relevant cell biological processes using a "molecular physiology" approach. This typically entails generation of molecular probes which are used to investigate dynamics of the process and/or protein-protein interactions in living neurons.  They have  used  a variety of high resolution imaging and biophysical approaches such as: multimode fluorescent speckle TIRF microscopy, laser trapping, photobleaching and "caged" probe photoactivation to achieve these ends. 
I have attached references for several of his recent papers below.   
 Alyson Fournier, PhD
Department of Neurology and Neurosurgery
Montreal Neurological Institute, BT-109
Montreal, Quebec
H3A2B4
TEL:  514-398-3154
FAX:  514-398-6547
email:  alyson.fournier at mcgill.ca
 

1:  Medeiros NA, Burnette DT, Forscher P. 
Myosin II functions in actin-bundle turnover in neuronal growth cones.
Nat Cell Biol. 2006 Feb 26; [Epub ahead of print] 
PMID: 16501565 [PubMed - as supplied by publisher]

2:  Qin H, Burnette DT, Bae YK, Forscher P, Barr MM, Rosenbaum JL. 
Intraflagellar transport is required for the vectorial movement of TRPV
channels in the ciliary membrane.
Curr Biol. 2005 Sep 20;15(18):1695-9. 
PMID: 16169494 [PubMed - in process]

3:  Suter DM, Schaefer AW, Forscher P. 
Microtubule dynamics are necessary for SRC family kinase-dependent growth cone
steering.
Curr Biol. 2004 Jul 13;14(13):1194-9. 
PMID: 15242617 [PubMed - indexed for MEDLINE]

4:  Zhang XF, Schaefer AW, Burnette DT, Schoonderwoert VT, Forscher P. 
Rho-dependent contractile responses in the neuronal growth cone are independent
of classical peripheral retrograde actin flow.
Neuron. 2003 Dec 4;40(5):931-44. 
PMID: 14659092 [PubMed - indexed for MEDLINE]

5:  Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM,
Waterman-Storer CM. 
Conserved microtubule-actin interactions in cell movement and morphogenesis.
Nat Cell Biol. 2003 Jul;5(7):599-609. Review. 
PMID: 12833063 [PubMed - indexed for MEDLINE]

6:  Nakhost A, Kabir N, Forscher P, Sossin WS. 
Protein kinase C isoforms are translocated to microtubules in neurons.
J Biol Chem. 2002 Oct 25;277(43):40633-9. Epub 2002 Aug 14. 
PMID: 12183453 [PubMed - indexed for MEDLINE]

7:  Schaefer AW, Kabir N, Forscher P. 
Filopodia and actin arcs guide the assembly and transport of two populations of
microtubules with unique dynamic parameters in neuronal growth cones.
J Cell Biol. 2002 Jul 8;158(1):139-52. Epub 2002 Jul 8. 
PMID: 12105186 [PubMed - indexed for MEDLINE]

8:  Suter DM, Forscher P. 
Transmission of growth cone traction force through apCAM-cytoskeletal linkages
is regulated by Src family tyrosine kinase activity.
J Cell Biol. 2001 Oct 29;155(3):427-38. Epub 2001 Oct 22. 
PMID: 11673478 [PubMed - indexed for MEDLINE]

9:  Kabir N, Schaefer AW, Nakhost A, Sossin WS, Forscher P. 
Protein kinase C activation promotes microtubule advance in neuronal growth
cones by increasing average microtubule growth lifetimes.
J Cell Biol. 2001 Mar 5;152(5):1033-44. 
PMID: 11238458 [PubMed - indexed for MEDLINE]

10:  Suter DM, Forscher P. 
Substrate-cytoskeletal coupling as a mechanism for the regulation of growth
cone motility and guidance.
J Neurobiol. 2000 Aug;44(2):97-113. Review. 
PMID: 10934315 [PubMed - indexed for MEDLINE]