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<div><b style="font-family:LucidaGrande">IBIS Week In Review</b><br>
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<div><b>9/6/2024</b></div>
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<div style="line-break:after-white-space"><b style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;"><br>
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<div style="line-break:after-white-space"><b style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;">IBIS EP</b></div>
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<div style="line-break:after-white-space"><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;"><span class="Apple-tab-span" style="font-weight: bold; white-space: pre;"></span>Data Lock</span></div>
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<div style="line-break:after-white-space"><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;">Sites should continue to work toward the uploading and final cleaning of all data before the planned data lock.</span></div>
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<div style="line-break:after-white-space"><font color="#000000" face="LucidaGrande"><span style="caret-color: rgb(0, 0, 0);">The data lock will occur: <b>OCTOBER 5, 2024</b></span></font></div>
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<div style="line-break:after-white-space"><b style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;">IBIS Funding News</b><br>
<blockquote style="margin: 0px 0px 0px 40px; border: medium; padding: 0px;">Congratulations to Tanya for receiving internal UW funding to look at IBIS EF data longitudinally!<br>
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<div style="line-break:after-white-space"><b style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;">IBIS EC Approvals</b></div>
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<div style="">Natasha and the Sex differences Workgroup - Paper Proposal</div>
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<div style=""><i>Investigating early sex differences in language in infants at increased familial risk of autism spectrum disorders</i></div>
<div style="">The work on this paper began with a medical student, Jackie, whom Natasha mentored and who presented our initial results at an INSAR meeting a few years ago. We found that at 12 months, HL males who went on to have ASD showed relatively lower
language compared to HL females who went on to have ASD. Since then, Kevin Donovan and Isa Stallworthy refined analyses and Tyler McFayden has joined the project and is taking the lead on getting this to the finish line. </div>
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Jason Stein - Presentation Proposal</blockquote>
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<blockquote style="margin: 0 0 0 40px; border: none; padding: 0px;"><i>Evaluating the fidelity of cortical organoids derived from induced pluripotent stem cells (iPSCs) to early human cerebral cortex development</i></blockquote>
<blockquote style="margin: 0 0 0 40px; border: none; padding: 0px;">An undergraduate who joined Jason's lab over the summer as part of the Carolina Summer Fellowship program is interested in presenting some of her work at an undergraduate conference (NeuroNovember). </blockquote>
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Meera - Paper Proposal<br>
<blockquote style="margin: 0 0 0 40px; border: none; padding: 0px;">Canonical babbling (CB), a combination of well-formed consonants and vowels, is one of the earliest speech milestones. It has been explored as a potential marker for speech-language delay
in neurodevelopmental disorders, but the findings are mixed. This study aimed to investigate CB in infants at elevated familial likelihood for ASD (EL-ASD) who later received an ASD diagnosis, compare them to elevated likelihood infants who did not develop
ASD (EL-Neg), and typically developing infants (LL-Neg). Data from 68 infants was collected using day-long audio recordings at 9 and 15 months using the Language ENvironment Analysis (LENA) digital language recorders. CB, CB ratios and CB stage (if CBR was
<0.15) were measured using naturalistic listening methods combined with hand annotations. Developmental and diagnostic assessments were conducted at 24 or 36 months. The study found that at 9 months, EL-ASD infants were less likely to reach the canonical babbling
stage compared to EL-Neg and LL-Neg infants. However, there were no significant differences in mean CBRs at 9 or 15 months among the three groups. Additionally, CBRs at 9 and 15 months were not associated with later language skills or autism severity. </blockquote>
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<div style="">Have a wonderful weekend everyone!</div>
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<div style="">Chad</div>
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