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<p class="MsoNormal">Thank you, Annette & others who have echoed her call for further discussing implications.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">And thank you for these good questions, Casey – <o:p></o:p></p>
<ol style="margin-top:0in" start="1" type="1">
<li class="MsoListParagraph" style="margin-left:0in;mso-list:l0 level1 lfo3">We did not conduct a latent class analysis but rather a latent class
<i>growth</i> analysis (related to an LPA, but allows for our three time points) (<a href="https://livejohnshopkins-my.sharepoint.com/:b:/g/personal/igorski1_jh_edu/EalOR1wdgvhPlE_zjWHbdC0BO6BsMDQonMjMYLzdSJ-Nfw?e=F0YAm8"><span class="MsoSmartlink"><img border="0" width="16" height="16" style="width:.1666in;height:.1666in" id="Picture_x0020_2" src="cid:image001.png@01D8FF43.1388BE10" alt="pdf icon">
00_Jung_et_al-2008-Social_and_Personality_Psychology_Compass.pdf</span></a>).<o:p></o:p></li><li class="MsoListParagraph" style="margin-left:0in;mso-list:l0 level1 lfo3">We adjusted for income as well as race/ethnicity as some of our
<i>a priori</i> confounders in our models and reported the adjusted effect estimates in the abstract (moved now to the figure).<o:p></o:p></li><li class="MsoListParagraph" style="margin-left:0in;mso-list:l0 level1 lfo3">That is another strategy we have considered, but have not utilized yet due to the complications you’re getting at. We have pivoted for now, for the full project but not for this abstract,
to more intricately evaluating the association between air pollution and brain volume (e.g., with distributed lag models looking at exposure windows over pregnancy), before we bring back ASD into the equation.<o:p></o:p></li></ol>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">I have attached a new version of the abstract (v3) addressing the comments thus far. Note: to make room for new words (limit = 300), I’ve moved some content to a figure (allowed/optional though potentially “cheating” by including words
in the figure).<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Best,<o:p></o:p></p>
<p class="MsoNormal">Irena<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><b>From:</b> Casey Burrows <cburrows@umn.edu> <br>
<b>Sent:</b> Wednesday, November 23, 2022 11:45 AM<br>
<b>To:</b> Annette Estes <estesa@uw.edu><br>
<b>Cc:</b> Girault, Jessica B. <jessica_girault@med.unc.edu>; ace-project@bic.mni.mcgill.ca; ace-analysis@bic.mni.mcgill.ca; Heather Volk <hvolk1@jhu.edu>; Irena Steiner <igorski1@jhu.edu><br>
<b>Subject:</b> Re: [Ace-project] Air pollution abstract - comments by 11/29<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
<p><b><br>
</b><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;color:white;background:red"> External Email - Use Caution </span></strong><o:p></o:p></p>
<p><o:p> </o:p></p>
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<p class="MsoNormal">Hi Irena, Heather and crew, <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">This is fantastic - very interesting use of this data, and interesting to see the air pollution data contributing to brain volume growth. I had a few questions/comments - this would pertain more to the full project as you are writing it
up. <o:p></o:p></p>
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<p class="MsoNormal">-Why did you conduct a latent class analysis, rather than modeling growth over time across the full sample? It seems like it would be simpler to start by modeling individuals' growth over time, and then predict that with your covariates
of interest. Especially when the LPA suggested a "low", "medium" and "high" group - to me that's saying that it might be better to model it continuously.<o:p></o:p></p>
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<p class="MsoNormal">-Did income and/or race/ethnicity covary with air pollution? How does including that impact your results?<o:p></o:p></p>
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<p class="MsoNormal">-If you do end up with the LPA model, would it make sense to consider a mediation approach where air pollution --> brain growth --> ASD outcome? To me that conceptually fits with the model you're proposing. But it also sounds very complicated
to model... <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Really interesting work! <o:p></o:p></p>
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<p class="MsoNormal">Casey<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">On Wed, Nov 23, 2022 at 10:26 AM Annette Estes <<a href="mailto:estesa@uw.edu">estesa@uw.edu</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">This is great! So happy to see the outcomes of this data collection effort. One thought – if you have the words available, it would be good to further discuss the implications
of these findings, rather than stopping at “this contrasts with observations of brain enlargement….”.
<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Thanks for your work on this!! Annette<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b>From:</b>
<a href="mailto:ace-project-bounces@bic.mni.mcgill.ca" target="_blank">ace-project-bounces@bic.mni.mcgill.ca</a> <<a href="mailto:ace-project-bounces@bic.mni.mcgill.ca" target="_blank">ace-project-bounces@bic.mni.mcgill.ca</a>>
<b>On Behalf Of </b>Girault, Jessica B.<br>
<b>Sent:</b> Wednesday, November 23, 2022 5:34 AM<br>
<b>To:</b> <a href="mailto:ace-project@bic.mni.mcgill.ca" target="_blank">ace-project@bic.mni.mcgill.ca</a>;
<a href="mailto:ace-analysis@bic.mni.mcgill.ca" target="_blank">ace-analysis@bic.mni.mcgill.ca</a><br>
<b>Cc:</b> Heather Volk <<a href="mailto:hvolk1@jhu.edu" target="_blank">hvolk1@jhu.edu</a>>; Irena Steiner <<a href="mailto:igorski1@jhu.edu" target="_blank">igorski1@jhu.edu</a>><br>
<b>Subject:</b> [Ace-project] Air pollution abstract - comments by 11/29<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black">Dear Colleagues, </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black">Heather Volk's team has an abstract for ISEE NAC describing analyses of pollution data in relation to brain volumes. </span><o:p></o:p></p>
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<span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<b><span style="font-size:12.0pt;color:black">Please see attached and provide and feedback to Irena, the first author (copied here), by 11/29. </span></b><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black">If you would like to be included as an author, please let her know. </span><o:p></o:p></p>
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<span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black">Thank you, </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span style="font-size:12.0pt;color:black">Jessica</span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p><span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
<p><span style="font-size:10.0pt;color:black">_____________________________________</span><o:p></o:p></p>
<p><span style="font-size:10.0pt;color:black">Jessica B. Girault, PhD</span><o:p></o:p></p>
<p><span style="font-size:10.0pt;color:black">Assistant Professor</span><o:p></o:p></p>
<p><span style="font-size:10.0pt;color:black">Carolina Institute for Developmental Disabilities</span><o:p></o:p></p>
<p><span style="font-size:10.0pt;color:black">Department of Psychiatry</span><o:p></o:p></p>
<p><span style="font-size:10.0pt;color:black">University of North Carolina at Chapel Hill</span><o:p></o:p></p>
<p><a href="https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefense.com%2Fv3%2F__https%3A%2Fgiraultlab.unc.edu%2F__%3B!!K-Hz7m0Vt54!nLi2kofkvGRWcZoasRXsZYHt2kITkMg13bp7KkfFvpPscqea98GoHOss2OB1HNqyjnAGtvhRiqeRaxJN14Q0bvopyNQ%24&data=05%7C01%7Cigorski1%40jhu.edu%7Cd82bcf2ab5994b61fb0608dacd722686%7C9fa4f438b1e6473b803f86f8aedf0dec%7C0%7C0%7C638048187406446694%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Y2VeiK0xSeyA9HNpUywTdUDn2eMFABsv0JaRklx6QEw%3D&reserved=0" target="_blank"><span style="font-size:10.0pt;background:white">https://giraultlab.unc.edu/</span></a><o:p></o:p></p>
<p><span style="font-size:12.0pt;color:black"> </span><o:p></o:p></p>
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<p class="MsoNormal">_______________________________________________<br>
Ace-project mailing list<br>
<a href="mailto:Ace-project@bic.mni.mcgill.ca" target="_blank">Ace-project@bic.mni.mcgill.ca</a><br>
<a href="https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmailman.bic.mni.mcgill.ca%2Fmailman%2Flistinfo%2Face-project&data=05%7C01%7Cigorski1%40jhu.edu%7Cd82bcf2ab5994b61fb0608dacd722686%7C9fa4f438b1e6473b803f86f8aedf0dec%7C0%7C0%7C638048187406446694%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=LAtVQN7ka5u8lPrsAzWTCKOhk2A%2BX6mZahqedeaDLKw%3D&reserved=0" target="_blank">https://mailman.bic.mni.mcgill.ca/mailman/listinfo/ace-project</a><o:p></o:p></p>
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<p class="MsoNormal">-- <o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">-----</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">Casey Burrows, PhD, LP<br>
Assistant Professor of Pediatrics</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">University of Minnesota</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">Autism and Neurodevelopment Clinic</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">Ph: 612-626-3834</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">Fax: 612-365-9050</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Cambria",serif;color:#595959">Pronouns: she/her/hers</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#333333">Note: The information transmitted in this e-mail is intended only for the person or entity to which it is addressed and may contain confidential and/or privileged
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